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In one embodiment, a fusion protein comprising a Tet repressor (TetR) from the Tc resistance operon of Escherichia coli transposon Tn10 fused to a transactivating domain (eg, that of VP16 from Herpes simplex virus) or a domain (eg, a dimerization domain) which recruits a transcriptional activator aleve ulcerative colitis an endogenous transcriptional activator) to interact with the fusion protein by a protein-protein interaction (eg, a non-covalent interaction) is introduced into a cell.
There is sufficient cross-recognition of the different tet operators by individual revTetR proteins (Klock et al.
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