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Examples of prodrug moieties include substituted and unsubstituted, branch or unbranched lower alkyl ester moieties, (eg, propionoic acid esters), lower alkenyl esters, di-lower alkylamino lower-alkyl esters (eg, dimethylaminoethyl ester), acylamino lower alkyl esters (eg, acetyloxymethyl ester), acyloxy lower alkyl esters (eg, pivaloyloxymethyl ester), aryl esters (phenyl ester), aryl-lower alkyl esters (eg, benzyl ester), substituted (eg, with methyl, halo, or methoxy substituents) aryl and aryl-lower alkyl esters, amides, lower-alkyl amides, di-lower alkyl amides, and hydroxy amides.